T6638

Tolnaftate

• Synonym(s): Methyl-(3-methylphenyl)carbamothioic acid O-2-naphthyl ester
• Empirical Formula (Hill Notation): C₁₉H₁₇NOS
• CAS Number: 2398-96-1
• Molecular Weight: 307.41
• EC Number: 219-266-6
• MDL number: MFCD00056611
• UNSPSC Code: 51302004
• PubChem Substance ID: 24900394
• NACRES: NA.85

Properties

• form: powder
• storage condition: (Keep container tightly closed in a dry and well-ventilated place.)
• color: white to off-white
• solubility: chloroform: soluble 50 mg/mL
• antibiotic activity spectrum: fungi
• Mode of action: enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3
• InChI: 1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3
• InChI key: FUSNMLFNXJSCDI-UHFFFAOYSA-N

Description

Application

Tolnaftate is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete′s foot, jock itch, and ringworm[1]. It also has been used as a comparator compound for antifungal efficiency studies[2].

Biochem/physiol Actions

Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms[1]. Tolnaftate inhibits biosynthesis of aflatoxin.

Packaging

1G,5G

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves