The cross reactivity of SRP6155 human BMP2 with rat has not been checked. However, literature indicates a high level of sequence homology between human and rat BMP2 (Freire et al., 2012; Freire et al., 2015) and VEGFA (Avivi et al., 1999; Ferrara, 2002) proteins. Accordingly, in many studies, human recombinant BMP2 and VEGFA have been used successfully in bone regeneration experiments in the rat (Park et al., 2003; Li et al., 2016). It is likely that SRP6155 should work with rat samples.
SRP6155
BMP-2 human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonym(s):
BMP-2A, Bone morphogenetic protein 2, Bone morphogenetic protein 2A
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
Pricing and availability is not currently available.
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biological source
human
recombinant
expressed in HEK 293 cells
Assay
≥95% (SDS-PAGE)
form
lyophilized
potency
20-100 ng/mL ED50
mol wt
30-38 kDa (homodimer, glycosylated)
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... BMP2(650)
General description
BMP2 (bone morphogenetic protein 2) belongs to the transforming growth factor-β (TGFβ) superfamily. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine.[1] BioVision′s BMP-2 is produced in a serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media and other applications.BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva.
Application
BMP-2 human has been used to study the biological role of it on adult renal progenitor cells under in vitro and in vivo conditions.[2]
Biochem/physiol Actions
BMPs (bone morphogenetic proteins) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues.[3] During bone repair, BMP-2 controls the expression of Runt-related transcription factor 2 (Runx2) and Osterix (Osx), thereby enhancing migration, proliferation and osteogenic differentiation of mesenchymal stem cells.[4] In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis.[5]
Physical form
Lyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl.
Preparation Note
Centrifuge the vial prior to opening.
Reconstitution
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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BMP-2 induces a profibrotic phenotype in adult renal progenitor cells through Nox4 activation.
Simone S, et al.
American Journal of Physiology: Renal Physiology, 303, F23-F34 (2012)
Rick Visser et al.
Tissue engineering. Part A, 20(1-2), 34-44 (2013-07-19)
Osteogenesis is a complex, multifactorial process in which many different signals interact. The bone morphogenetic proteins (BMPs) are the most potent inducers of osteoblastic differentiation, although very high doses of BMPs in combination with collagen type I formulations have to
Vera Hintze et al.
Biomacromolecules, 15(8), 3083-3092 (2014-07-17)
Sulfated glycosaminoglycans (GAGs) can direct cellular processes by interacting with proteins of the extracellular matrix (ECM). In this study we characterize the interaction profiles of chemically sulfated hyaluronan (HA) and chondroitin sulfate (CS) derivatives with bone morphogenetic protein-2 (BMP-2) and
Ivo Dumic-Cule et al.
International orthopaedics, 38(9), 1979-1985 (2014-07-18)
Bone morphogenetic protein (BMP)-2 and -7 are used in patients with long-bone fractures, nonunions and spinal fusions. It is unknown whether their potential systemic bioavailability following local bone administration might affect skeletal metabolism. To answer this question, we examined effects
Elisabeth Aubert-Foucher et al.
Matrix biology : journal of the International Society for Matrix Biology, 34, 80-88 (2013-09-24)
Type II collagen, the major fibrillar collagen of cartilage, is synthesized as precursor forms (procollagens) containing N- and C-terminal propeptides. Three splice variants are thought to be translated to produce procollagen II isoforms (IIA/D and IIB) which differ in their
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Could you please provide information on the cross-reactivity of SRP6155 with rats?
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