Skip to Content
Merck
All Photos(1)

Documents

SML3571

Sigma-Aldrich

GS-621763

≥98% (HPLC)

Synonym(s):

(2R,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-5-((isobutyryloxy)methyl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate)

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C24H31N5O7
CAS Number:
2647442-13-3
Molecular Weight:
501.53
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N#C[C@@]1(C2=CC=C3C(N)=NC=NN32)O[C@@H]([C@H]([C@H]1OC(C(C)C)=O)OC(C(C)C)=O)COC(C(C)C)=O

Biochem/physiol Actions

GS-621763 is an orally bioavailable analog of remdesivir, which is efficiently converted in plasma to active metabolite GS-441524, or in lungs to the bioactive triphosphate GS-443902. GS-621763 effectively reduces SARS-CoV-2 burden to near-undetectable levels in ferrets.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets
Nature Communications, 12, 6415-6415 (2021)
Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV
Journal of Medicinal Chemistry, 64, 5001-5017 (2021)
Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice
Science Translational Medicine, 14 (2022)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service