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SML2779

Sigma-Aldrich

Tanaproget

≥98% (HPLC)

Synonym(s):

5-(1,4-Dihydro-4,4-dimethyl-2-thioxo-2H-3,1-benzoxazin-6-yl)-1-methyl-1H-pyrrole-2-carbonitrile, 5-(4,4-Dimethyl-2-thioxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-1-methyl-1H-pyrrole-2-carbonitrile, NSP 989

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About This Item

Empirical Formula (Hill Notation):
C16H15N3OS
CAS Number:
304853-42-7
Molecular Weight:
297.37
MDL number:
MFCD18450396
UNSPSC Code:
51111800
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

InChI

1S/C16H15N3OS/c1-16(2)12-8-10(4-6-13(12)18-15(21)20-16)14-7-5-11(9-17)19(14)3/h4-8H,1-3H3,(H,18,21)

InChI key

PYVFWTPEBMRKSR-UHFFFAOYSA-N

Biochem/physiol Actions

Tanaproget is a high affinity, high efficacy and selective orally available non-steroidal progesterone receptor agonist.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360FD

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Certificates of Analysis (COA)

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Jody L Bapst et al.
Contraception, 74(5), 414-418 (2006-10-19)
This study aimed to evaluate the pharmacokinetics, pharmacodynamics and safety of the nonsteroidal progesterone receptor agonist, tanaproget. A randomized, double-blind, placebo-controlled, sequential-group study of ascending single doses of tanaproget was conducted in healthy, 25- to 45-year-old women on cycle days
Louis Allott et al.
EJNMMI radiopharmacy and chemistry, 4(1), 1-1 (2019-10-30)
The histological evaluation of estrogen receptor (ER) and progesterone receptor (PR) expression in breast cancer lesions from biopsy tissue can stratify patients to receive endocrine therapy. Furthermore, PR expression can predict response to selective estrogen receptor modulators (SERMs). Current immunohistochemical
Richard C Winneker et al.
Steroids, 73(7), 689-701 (2008-05-13)
Progesterone receptor (PR) modulators have evolved both structurally and mechanistically over the past half-century. Classical steroidal PR agonists continue to play an important role in women's health such as in oral contraception and post-menopausal hormone therapy whereas steroid-based PR antagonists

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