SML1526

Eltoprazine hydrochloride

≥98% (HPLC)

• Synonym(s): 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-piperazine hydrochloride
• Empirical Formula (Hill Notation): C₁₂H₁₆N₂O₂ · HCl
• CAS Number: 98206-09-8
• Molecular Weight: 256.73
• MDL number: MFCD06245586
• UNSPSC Code: 12352202
• PubChem Substance ID: 329825943
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 10 mg/mL, clear
• storage temp.: room temp
• SMILES string: [H]Cl.C1(OCCO2)=C2C(N3CCNCC3)=CC=C1
• InChI: 1S/C12H16N2O2.ClH/c1-2-10(14-6-4-13-5-7-14)12-11(3-1)15-8-9-16-12;/h1-3,13H,4-9H2;1H
• InChI key: JFSOSUNPIXJCIX-UHFFFAOYSA-N

Description

General description

Eltoprazine, a serotonergic agent, possesses specific anti-aggressive (serenic) properties in various animal models without triggering sedation, motor disturbances, or muscle relaxation.

Biochem/physiol Actions

Eltoprazine hyrochloride is a serotonin 5-HT1A/1B receptor agonist that has been shown to reduce L-DOPA-induced dyskinesias in in experimental models of Parkinson′s Disease and in human patients. It has Ki values for 5-HT1A, 5-HT1B and 5-HT1C receptors of 40 nM and 52 nM, respectively.

Serotonin 5-HT1A/1B receptor agonist

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301,H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable