SAB3500929

Anti-RIFT VALLEY FEVER VIRUS antibody produced in rabbit

affinity isolated antibody

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: virus
• concentration: 1 mg/mL
• technique(s): ELISA: suitable
• UniProt accession no.: P03518
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified

Description

General description

Rift valley fever virus (RVFV) is an enveloped RNA virus belonging to the Phlebovirus genus of the family Bunyaviridae. RVFV possesses a single stranded segmented RNA genome composed of a large (L), a medium (M), and a small (S) segment. The L segment codes for the RNA-dependent RNA polymerase. The M segment codes for a polyprotein which is the precursor to the glycoproteins G1 and G2 and two non-structural proteins, 14K and 78K. The S segment codes for the nucleoprotein N and the non-structural protein NSs.

Immunogen

Antibody was raised against a 20 amino acid synthetic peptide near the center of the RVF virus.

Biochem/physiol Actions

Rift valley fever virus (RVFV) causes rift valley fever (RVF), an arthropod-borne viral disease. The virus is transmitted either by an arthropod or direct transmission by contact or aerosol among the hosts. The non-structural phosphoprotein (NSs) is responsible for the virulence in the pathogenic RVFV and suppresses human interferon gene expression. The fever is mainly observed in sheep and cattle. In humans, RVF clinical symptoms includes benign fever to severe encephalitis, retinitis, and fatal hepatitis with haemorrhagic fever. RVFV may block α/β interferon (IFN-α/β) expression in host and may target transcription factor aswell TFIIH.

Features and Benefits

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Linkage

The action of this antibody can be blocked using blocking peptide SBP3500929.

Physical form

Supplied at 1 mg/mL in PBS with 0.02% sodim azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable