Androgen receptor (AR) is a nuclear transcription factor. It belongs to the steroid hormone receptor superfamily. AR gene is located on human chromosome Xq12. AR is present in endothelial and vascular smooth muscle cells.
Immunogen
Peptide with sequence EVQLGLGRVYPRPPSC from the N Terminus of the protein sequence according to NP_000035.2.
Biochem/physiol Actions
Androgens like testosterone and 5α-dihydrotestosterone are required for the progression, growth, differentiation and maintenance of organ structure of the prostate. It plays a major role in normal and malignant breast tissue.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
FISH analysis of gene aberrations (MYC, CCND1, ERBB2, RB, and AR) in advanced prostatic carcinomas before and after androgen deprivation therapy.
Kaltz-Wittmer C, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 80(9), 1455?1464-1455?1464 (2000)
The CAG repeat polymorphism in the AR gene affects high density lipoprotein cholesterol and arterial vasoreactivity.
Zitzmann M, et al.
The Journal of Clinical Endocrinology and Metabolism, 86(10), 4867-4873 (2001)
Androgen receptor expression on circulating tumor cells in metastatic breast cancer.
Fujii T, et al.
PLoS ONE, 12(9), e0185231-e0185231 (2016)
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