N3288

(+)-Norfenfluramine hydrochloride

≥98% (HPLC), powder

• Synonym(s): JP 92, NSC 43036, S-(+)-α-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
• Empirical Formula (Hill Notation): C₁₀H₁₂F₃N · HCl
• CAS Number: 37936-89-3
• Molecular Weight: 239.67
• MDL number: MFCD11045299
• UNSPSC Code: 12352116
• PubChem Substance ID: 329818604
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• drug control: regulated under CDSA - not available from Sigma-Aldrich Canada
• storage condition: desiccated
• color: white
• solubility: H₂O: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.C[C@H](N)Cc1cccc(c1)C(F)(F)F
• InChI: 1S/C10H12F3N.ClH/c1-7(14)5-8-3-2-4-9(6-8)10(11,12)13;/h2-4,6-7H,5,14H2,1H3;1H/t7-;/m0./s1
• InChI key: PIDLOFBRTWNFAR-FJXQXJEOSA-N

Description

Biochem/physiol Actions

(+)-Norfenfluramine is the major hepatic metabolite of (+)-fenfluramine and is primarily responsible for the anorexic effect, as well as side effects; (+)-norfenfluramine causes vasoconstriction and a blood pressure increase in rats with normal blood; acts primarily on the cytoplasmic pool of serotonin; more potent than fenfluramine at inducing dopamine release.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves