M9940
Mercaptoethylguanidine hemisulfate salt
≥98%
Synonym(s):
MEG hemisulfate salt
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About This Item
Linear Formula:
H2NC(=NH)NHSCH2CH3 · 1/2 H2SO4
CAS Number:
Molecular Weight:
168.23
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Assay
≥98%
form
solid
shipped in
wet ice
storage temp.
2-8°C
SMILES string
OS(O)(=O)=O.NC(=N)NCCS.NC(=N)NCCS
InChI
1S/2C3H9N3S.H2O4S/c2*4-3(5)6-1-2-7;1-5(2,3)4/h2*7H,1-2H2,(H4,4,5,6);(H2,1,2,3,4)
InChI key
XJKZAAUVINNNNC-UHFFFAOYSA-N
Application
Selective iNOS inhibitor and scavenger of peroxynitrite.
Biochem/physiol Actions
Demonstrates potent antiinflammatory effects in an animal model of airway infection that mimics human cystic fibrosis.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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A Wolfárd et al.
Shock (Augusta, Ga.), 13(1), 46-51 (2000-01-19)
In our study the pathomechanism of sepsis-induced early myocardial depression was investigated. We determined the effects of the inducible nitric oxide synthase inhibitor and free radical scavenger mercaptoethylguanidine (MEG) on the myocardial contractility, the endothelial and inducible nitric oxide synthase
Steve Lancel et al.
Journal of the American College of Cardiology, 43(12), 2348-2358 (2004-06-15)
The aim of this study was to test whether peroxynitrite neutralizers would reduce peroxynitrite accumulation and improve myocardial contractile dysfunction and inflammation in endotoxin-treated rats. Release of endogenous proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha in response to endotoxin
The effect of inducible nitric oxide synthase (iNOS) inhibition on smoke inhalation injury in sheep.
K Soejima et al.
Shock (Augusta, Ga.), 13(4), 261-266 (2000-04-25)
Recent studies on smoke inhalation injury have been focused on nitric oxide (NO) as an essential factor of progressive lung injury. We studied the effects of inducible nitric oxide synthase (iNOS) inhibition on inhalation injury in sheep. Sheep (n =
K Soejima et al.
American journal of respiratory and critical care medicine, 163(3 Pt 1), 745-752 (2001-03-20)
Patients with severe burn and/or smoke inhalation injury suffer both systemic and pulmonary vascular hyperpermeability. We hypothesized that nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) plays a role in the changes in microvascular permeability seen with this
M Kiroycheva et al.
Journal of the American Society of Nephrology : JASN, 11(6), 1026-1032 (2000-05-23)
Previous studies in beta(s) sickle cell mice demonstrated renal immunostaining for nitrotyrosine, which is putative evidence of peroxynitrite (ONOO(-)) formation. ONOO(-) is known to nitrate tyrosine residues of various enzymes, thereby interfering with phosphorylation and inactivating them. The present study
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