K2380
D-Kynurenine
Synonym(s):
β-Anthraniloyl-D-alanine, D-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
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About This Item
Empirical Formula (Hill Notation):
C10H12N2O3
CAS Number:
Molecular Weight:
208.21
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.26
Recommended Products
Assay
≥98% (TLC)
form
powder
technique(s)
ligand binding assay: suitable
color
faint yellow to yellow
application(s)
cell analysis
SMILES string
N[C@H](CC(=O)c1ccccc1N)C(O)=O
InChI
1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m1/s1
InChI key
YGPSJZOEDVAXAB-MRVPVSSYSA-N
Biochem/physiol Actions
D-Kynurenine may be used along with L-kynurenine to assess the specificity and kinetics of kynurenine metabolizing enzymes. D-Kynurenine is used to study the selectivity and activity of the G protein-coupled receptor, GPR109B. D-Kynurenine is used as a substrate in a fluorometric assay of D-amino acid oxidase.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Olger Huaman et al.
Research in veterinary science, 124, 212-222 (2019-03-30)
Little information is currently available on therapeutic features of bovine mesenchymal stem cells (MSCs), despite the development of large animal experimental models including cattle may open alternative strategies for investigating MSC physiology and eventual applications for regenerative therapy. The aim
Masato Hoshi et al.
Toxicology, 438, 152458-152458 (2020-04-15)
Kynurenine (Kyn) plays an important role as an immune check-point molecule and regulates various immune responses through its aryl hydrocarbon receptor (Ahr). Kyn is synthesized by indoleamine 2,3-dioxygenase (Ido) and tryptophan 2,3-dioxygenase (Tdo). Ido contributes approximately 90% of tryptophan catabolism.
Sumiko Iwasa et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 131(7), 1111-1116 (2011-07-02)
A facile fluorometric assay using D-kynurenine as a substrate was utilized for evaluating the inhibition of D-amino acid oxidase (DAAO), which is one of the products of a susceptibility gene for schizophrenia, by commercial antipsychotic drugs, namely, chlorpromazine (CPZ), carbamazepine
Aysha Sarfraz Rizvi et al.
Journal of chromatography. A, 1622, 461128-461128 (2020-04-26)
We present high resolution fast, cost-effective and sensitive Capillary zone electrophoresis (CZE) methods for determination of enantiomeric compounds of Kynurenine pathway, i.e. D, L-Kynurenine (KYN), in human serum and urine samples by cationic-β-CD and its synergistic dual chiral selector system
Kana Ishii et al.
Chirality, 22(10), 901-906 (2010-09-28)
An aqueous solution of enantiomerically pure tryptophan (Trp), namely, D-Trp or L-Trp (100 mg/kg), was administered intraperitoneally to male Sprague-Dawley rats. The time-course profiles of the rat plasma concentrations of D-kynurenine (KYN), L-KYN, and kynurenic acid (KYNA), which are metabolites
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