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Key Documents

HPA038021

Sigma-Aldrich

Anti-LPIN1 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-KIAA0188, Anti-Lipin 1

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About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.41

Pricing and availability is not currently available.

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500

General description

Lipin 1 (LPIN1) gene with 19 exons is mapped to human chromosome 2p25.1. The encoded protein contains 890 amino acids and is mainly expressed in skeletal muscles and adipose tissue. In humans and mice, LPIN1 exists in three isoforms, namely lipin-1α, β, andγ. LPIN1 belongs to the family of phosphatidic acid (PA) phosphohydrolases.

Immunogen

lipin 1 recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Biochem/physiol Actions

Lipin 1 (LPIN1) catalyzes the dephosphorylation of phosphatidic acid to diacylglycerol (DAG), which is a precursor of triglycerides. The encoded protein has been implicated in adipogenesis, abdominal obesity, insulin resistance and hypertriglyceridemia. Mutation in the gene is linked to rhabdomyolysis (RM), a disease characterized by skeletal muscle damage leading to myoglobinuria and acute renal failure. In addition, variation in the gene expression is also associated with hypertension and blood pressure.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST70478

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lipid signaling in keratinocytes: Lipin-1 plays a PArt.
Bollag WB
Journal of Lipid Research, 57, 523-525 (2016)
Molecular analysis of LPIN1 in Jordanian patients with rhabdomyolysis.
Jaradat SA
Meta Gene, 90-94 (2015)
LPIN1 deficiency: A novel mutation associated with different phenotypes in the same family.
Nunes D
Molecular genetics and metabolism reports, 9, 29-30 (2016)
Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men.
Ong KL
American Journal of Hypertension, 21, 539-545 (2008)

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