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H156

Sigma-Aldrich

(+)-3-Hydroxymorphinan hydrobromide

neurotrophic to dopaminergic neurons

Synonym(s):

(+)-9α,13α,14α-Morphinan-3-ol

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About This Item

Empirical Formula (Hill Notation):
C16H21NO · HBr
CAS Number:
15676-23-0
Molecular Weight:
324.26
UNSPSC Code:
12352204
PubChem Substance ID:
329815168
Pricing and availability is not currently available.

description

neurotrophic to dopaminergic neurons

Quality Level

100

Assay

≥98% (HPLC)

form

powder

drug control

USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada

SMILES string

Br.Oc1ccc2C[C@@H]3NCC[C@]4(CCCC[C@H]34)c2c1

InChI

1S/C16H21NO.BrH/c18-12-5-4-11-9-15-13-3-1-2-6-16(13,7-8-17-15)14(11)10-12;/h4-5,10,13,15,17-18H,1-3,6-9H2;1H/t13-,15+,16+;/m1./s1

InChI key

LJAQABDSIONCIU-KHUAAREISA-N

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
022M4611V
120K4600

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Jong Yup Kim et al.
Chemical & pharmaceutical bulletin, 56(7), 985-987 (2008-07-02)
Dimemorfan (DF) has been known to possess neuroprotective properties. While this promising compound deserves further biological evaluation, synthetic methods have not improved since Murakami group unveiled the synthetic efforts in 1972. Herein a succinct synthesis toward DF from commercially available
High-performance liquid chromatographic determination of dextrorphan and 3-hydroxymorphinan in human plasma based on a selective pre-column sample clean-up.
H Mascher
Journal of chromatography, 420(1), 217-222 (1987-09-04)
Z R Chen et al.
Therapeutic drug monitoring, 12(1), 97-104 (1990-01-01)
A simple, sensitive, and reproducible high-performance liquid chromatrography assay is described for the simultaneous determination of dextromethophan, dextrorphan, 3-hydroxymorphinan, and 3-methoxymorphinan in plasma and urine. A conventional solvent-solvent extraction procedure was used for the isolation of the analytes from plasma
K C Carlsson et al.
Acta anaesthesiologica Scandinavica, 48(3), 328-336 (2004-02-26)
Dextromethorphan, a clinically available N-methyl-D-aspartic acid (NMDA) receptor antagonist, has an analgesic effect in patients with diabetic neuropathy. The aim of this study was to evaluate the analgesic and adverse effects of a single high dose of dextromethorphan on spontaneous
S J Vetticaden et al.
Pharmaceutical research, 6(1), 13-19 (1989-01-01)
Polymorphic differences in dextromethorphan metabolism were observed in three studies conducted in a total of 44 subjects (of Dutch origin) administered 60 mg dextromethorphan hydrobromide as an OROS tablet. Mean plasma dextromethorphan (DM) concentrations after a single dose and at
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