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EHU067991

Sigma-Aldrich

MISSION® esiRNA

targeting human CNKSR1

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About This Item

UNSPSC Code:
41105324
NACRES:
NA.51

description

Powered by Eupheria Biotech

Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

GGGACACACGCTCTACTGGTACCGCCAGCCCCAGGATGAGAAGGCTGAGGGCCTCATCAATGTCTCCAACTATAGTCTGGAAAGTGGACATGATCAGAAGAAGAAATATGTGTTTCAGCTCACCCATGATGTGTACAAACCCTTCATCTTCGCTGCTGATACCCTGACAGATCTGAGCATGTGGGTGCGTCATCTCATTACCTGCATCTCCAAGTACCAGTCTCCAGGCCGGGCCCCCCCACCCCGAGAGGAAGACTGCTACAGTGAGACCGAAGCAGAGGACCCGGACGATGAGGCTGGGTCCCACTCAGCCTCGCCCAGCCCTGCTCAAGCTGGGAGTCCCCTCCATGGAGACACATCACCTGCAGCCACCCCCACACAGCGCAGCCCACGGACCTCCTTTGGCTCTCTGA

Ensembl | human accession no.

ENSG00000142675

NCBI accession no.

NM_006314

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... CNKSR1(10256) , CNKSR1(10256)

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Adrian Fischer et al.
Scientific reports, 6, 38155-38155 (2016-12-03)
Scaffold proteins such as the multidomain protein CNK1 orchestrate the signalling network by integrating and controlling the underlying pathways. Using an optogenetic approach to stimulate CNK1 uncoupled from upstream effectors, we identified selective clusters of CNK1 that either stimulate RAF-MEK-ERK
Martin Indarte et al.
Cancer research, 79(12), 3100-3111 (2019-05-02)
Cnk1 (connector enhancer of kinase suppressor of Ras 1) is a pleckstrin homology (PH) domain-containing scaffold protein that increases the efficiency of Ras signaling pathways, imparting efficiency and specificity to the response of cell proliferation, survival, and migration. Mutated KRAS

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