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D7946

Sigma-Aldrich

DIM-C-pPhOCH3

≥98% (HPLC)

Synonym(s):

1,1-bis(3′-Indolyl)-1-(p-methoxyphenyl)methane; 3,3′-[(4-Methoxyphenyl)methylene]bis-1H-indole

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About This Item

Empirical Formula (Hill Notation):
C24H20N2O
CAS Number:
33985-68-1
Molecular Weight:
352.43
MDL number:
MFCD01217840
UNSPSC Code:
12352200
PubChem Substance ID:
329798790
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

off-white to light yellow

solubility

DMSO: ≥30 mg/mL

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)C(c2c[nH]c3ccccc23)c4c[nH]c5ccccc45

InChI

1S/C24H20N2O/c1-27-17-12-10-16(11-13-17)24(20-14-25-22-8-4-2-6-18(20)22)21-15-26-23-9-5-3-7-19(21)23/h2-15,24-26H,1H3

InChI key

ZCCMKJAXOIFTHH-UHFFFAOYSA-N

Biochem/physiol Actions

DIM-C-pPhOCH3 is a Nerve Growth Factor-Induced Bα (NGFI-Bα, Nur77) agonist

Features and Benefits

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
090M4617

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Katriana A Popichak et al.
Molecular pharmacology, 94(4), 1174-1186 (2018-08-17)
Inflammatory activation of glial cells promotes loss of dopaminergic neurons in Parkinson disease. The transcription factor nuclear factor κB (NF-κB) regulates the expression of multiple neuroinflammatory cytokines and chemokines in activated glial cells that are damaging to neurons. Thus, inhibition

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