A9102

AH13205

≥98% (HPLC), oil

• Synonym(s): trans-2-(4-(1-Hydroxyhexyl)phenyl-5-oxocyclopentaneheptanoic acid
• Empirical Formula (Hill Notation): C₂₄H₃₆O₄
• CAS Number: 148436-63-9
• Molecular Weight: 388.54
• MDL number: MFCD00797641
• UNSPSC Code: 12352200
• PubChem Substance ID: 329771031
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: oil
• color: pale yellow
• solubility: DMSO: >10 mg/mL
• originator: GlaxoSmithKline
• storage temp.: −20°C
• SMILES string: CCCCCC(O)c1ccc(cc1)[C@H]2CCC(=O)[C@@H]2CCCCCCC(O)=O
• InChI: 1S/C24H36O4/c1-2-3-6-10-22(25)19-14-12-18(13-15-19)20-16-17-23(26)21(20)9-7-4-5-8-11-24(27)28/h12-15,20-22,25H,2-11,16-17H2,1H3,(H,27,28)/t20-,21-,22?/m1/s1
• InChI key: XMQKDOCUWFCMEJ-JAZPPYFYSA-N

Description

General description

AH13205 is EP₂ prostanoid receptor agonist. There are five types of prostanoid receptors, which are classified based on sensitivity to the five naturally-occuring prostanoid ligand. The EP type of receptor is further divided into four subgroups – EP₁, EP₂, EP₃ and EP₄. EP₂ activation results in vascular, bronchial and reproductive smooth muscle relaxation.

Biochem/physiol Actions

AH13205 is a selective, low potency agonist for the EP₂ receptor. AH13205 has been shown to compete with Prostaglandin E2 (PGE2) for binding, resulting in the displacement of PGE2 binding.

Features and Benefits

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves