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89870

Sigma-Aldrich

Toluene 2,4-diisocyanate

purum, suitable for electron microscopy, ≥98.0% (GC)

Synonym(s):

2,4-Diisocyanatotoluene, 4-Methyl-m-phenylene diisocyanate, Tolylene 2,4-diisocyanate

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About This Item

Empirical Formula (Hill Notation):
C9H6N2O2
CAS Number:
584-84-9
Molecular Weight:
174.16
Beilstein:
744602
EC Number:
209-544-5
MDL number:
MFCD00002011
UNSPSC Code:
12352200
PubChem Substance ID:
57653363
NACRES:
NA.25

grade

purum

Quality Level

200

Assay

≥98.0% (GC)

form

liquid

technique(s)

electron microscopy: suitable

refractive index

n20/D 1.567

bp

124-126 °C/18 mmHg (lit.)
251 °C (lit.)

mp

19.5-21.5 °C (lit.)

density

1.21 g/mL at 20 °C
1.22 g/mL at 20 °C (lit.)

SMILES string

Cc1ccc(cc1N=C=O)N=C=O

InChI

1S/C9H6N2O2/c1-7-2-3-8(10-5-12)4-9(7)11-6-13/h2-4H,1H3

InChI key

DVKJHBMWWAPEIU-UHFFFAOYSA-N

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Application

Toluene 2,4-diisocyanate is used to study it occupational hazards (asthma, dermatitis) and mechanisms of action. Reagent for covalent protein crosslinking; For the immobilization of antibodies to a plastic surface for RIA

Other Notes

Reagent for covalent protein crosslinking; For the immobilization of antibodies to a plastic surface for RIA

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

Flash Point(F)

269.6 °F - closed cup

Flash Point(C)

132 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Shuyu Chen et al.
Allergy, asthma & immunology research, 12(4), 608-625 (2020-05-14)
Accumulating evidence has suggested that toll-like receptor 4 (TLR4) is critically involved in the pathogenesis of asthma. The aim of this study was to investigate the role of TLR4 in toluene diisocyanate (TDI)-induced allergic airway inflammation. TLR4-/- and wild-type (WT)
T Saito et al.
Clinica chimica acta; international journal of clinical chemistry, 133(3), 301-310 (1983-10-14)
A novel procedure to fix antibody on a plastic surface was developed, using a polystyrene tube treated with 0.5% toluene 2,4-diisocyanate (TC) dissolved in carbon tetrachloride. Using 125I-labelled IgG, we found that the rate of immobilization of IgG was significantly
[57] Bifunctional reagents.
F Wold
Methods in enzymology, 25, 623-651 (1972-01-01)
Tatiana Kuznetsova et al.
American journal of hypertension, 28(4), 535-545 (2014-09-23)
The cardio-renal interaction occurs via hemodynamic and humoral factors. Noninvasive assessment of renal hemodynamics is currently possible by assessment of renal resistive index (RRI) derived from intrarenal Doppler arterial waveforms as ((peak systolic velocity - end-diastolic velocity)/peak systolic velocity). Limited
Norman Mangner et al.
JACC. Cardiovascular imaging, 7(12), 1198-1205 (2014-10-13)
The aim of our study was to assess geometric and functional changes of the heart in obese compared with nonobese children and adolescents. Obesity in children and adolescents has increased over the past decades and is considered a strong risk
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