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51010

Sigma-Aldrich

4-Methylumbelliferyl 4-guanidinobenzoate hydrochloride hydrate

≥85% (HPLC)

Synonym(s):

4-Guanidinobenzoic acid 4-methylumbelliferyl ester hydrochloride, MUGB

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About This Item

Empirical Formula (Hill Notation):
C18H15N3O4 · HCl · xH2O
CAS Number:
34197-46-1
Molecular Weight:
373.79 (anhydrous basis)
EC Number:
251-871-0
MDL number:
MFCD00043263
UNSPSC Code:
12352204
PubChem Substance ID:
57651297

Assay

≥85% (HPLC)

form

powder

fluorescence

λex 323 nm; λem 464 nm (solvent pH 6.0)
λex 360 nm; λem 449 nm (Reaction Product)

storage temp.

2-8°C

SMILES string

Cl[H].CC1=CC(=O)Oc2cc(OC(=O)c3ccc(NC(N)=N)cc3)ccc12

InChI

1S/C18H15N3O4.ClH/c1-10-8-16(22)25-15-9-13(6-7-14(10)15)24-17(23)11-2-4-12(5-3-11)21-18(19)20;/h2-9H,1H3,(H4,19,20,21);1H

InChI key

DAFWZROYEOVJAL-UHFFFAOYSA-N

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Other Notes

Fluorimetric titrant for α- and β-trypsin, thrombin and Factor Xa

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Some sensitive methods for the assay of trypsinlike enzymes.
P L Coleman et al.
Methods in enzymology, 45, 12-26 (1976-01-01)
Lambro A Johnson et al.
Analytical biochemistry, 608, 113907-113907 (2020-08-20)
Snake venom prothrombin activators such as Ecarin are readily assayed by continuous spectrophotometric monitoring of p-nitroaniline production in a one step assay containing prothrombin and a p-nitroanilide peptide substrate for thrombin. The coupled reactions result in accelerating p-nitroaniline (pNA) production
G W Jameson et al.
The Biochemical journal, 131(1), 107-117 (1973-01-01)
Several esters of 4-methylumbelliferone and 2-naphthol were synthesized and examined as possible spectrofluorimetric titrants for bovine alpha-chymotrypsin, trypsin, thrombin, Factor Xa and for subtilisin Novo. 4-Methylumbelliferyl p-guanidinobenzoate hydrochloride (MUGB) is a satisfactory titrant for alpha- and beta-trypsin, thrombin and Factor
J Grandoni et al.
Haemophilia : the official journal of the World Federation of Hemophilia, 23(2), 300-308 (2016-12-21)
LR769 is a new second-generation recombinant human Factor VIIa (rhFVIIa) developed for haemophilia treatment. We determined enzymatic properties of LR769 and its interaction with antithrombin, tissue factor, platelets and endothelial protein C receptor (EPCR), compared with NovoSevenRT. Kinetic enzyme assays
Simon J de Veer et al.
The Biochemical journal, 469(2), 243-253 (2015-05-20)
Laskowski inhibitors regulate serine proteases by an intriguing mode of action that involves deceiving the protease into synthesizing a peptide bond. Studies exploring naturally occurring Laskowski inhibitors have uncovered several structural features that convey the inhibitor's resistance to hydrolysis and

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