483R-1

p40 (ZR8) Rabbit Monoclonal Antibody

• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• Quality Level: 100; 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: ZR8
• description: For In Vitro Diagnostic Use in Select Regions
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (483R-14); vial of 0.1 mL concentrate, Research Use Only (483R-14-RUO); vial of 0.5 mL concentrate (483R-15); vial of 1.0 mL concentrate (483R-16); vial of 1.0 mL concentrate, Research Use Only (483R-16-RUO); vial of 1.0 mL pre-dilute, Research Use Only (483R-17-RUO); vial of 1.0 mL pre-dilute, ready to use (483R-17); vial of 25.0 mL pre-dilute, ready-to-use (483R-10); vial of 25.0 mL pre-dilute, ready-to-use, Research Use Only (483R-10-RUO); vial of 7.0 mL pre-dilute, ready to use (483R-18); vial of 7.0 mL pre-dilute, ready to use, Research Use Only (483R-18-RUO)
• manufacturer/tradename: Cell Marque
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (1:100-1:200 (concentrated))
• isotype: IgG
• control: lung (squamous cell carcinoma), prostate, urothelial carcinoma
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: nuclear

Description

General description

p40 is an isoform of p63, a transcription factor that regulates many cell activities, including cell proliferation, maintenance, and differentiation. It performs as a sensitive and specific tool for aiding in the identification of squamous cell carcinoma of the lung. In addition to its utility as a squamous differentiation marker, p40 has also been proven to be a valuable marker for highlighting myoepithelial and basal cell populations in prostate, breast, skin, and salivary gland.^1-5 Strong p40 expression is frequently observed in esophageal cancerous squamous lesions.⁶ Immunohistochemical detection of p40 can also be helpful in identifying urothelial carcinoma.⁷ In cases of prostate carcinoma, p40 is almost always found to be negative for basal cell staining.⁸

Quality

• United States - IVD
• Canada - RUO
• European Union - IVD
• Japan - RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Note: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable