39286

Hydroxystilbamidine bis(methanesulfonate)

suitable for fluorescence, ≥96.0% (HPLC)

• Synonym(s): 2-Hydroxystilbene-4,4′-dicarboxamidine bis(methanesulfonate), Fluoro-Gold
• Empirical Formula (Hill Notation): C₁₈H₂₄N₄O₇S₂
• CAS Number: 223769-64-0
• Molecular Weight: 472.54
• NACRES: NA.32
• PubChem Substance ID: 57649893
• UNSPSC Code: 41116100
• MDL number: MFCD01863083

Properties

• Quality Segment: 100
• assay: ≥96.0% (HPLC)
• form: powder
• fluorescence: λ_ex 340 nm nm in phosphate buffer (pH 6.0 with DNA)
• suitability: suitable for fluorescence
• storage temp.: 2-8°C
• SMILES string: CS(O)(=O)=O.CS(O)(=O)=O.NC(=N)c1ccc(cc1)\C=C\c2ccc(cc2O)C(N)=N
• InChI: 1S/C16H16N4O.2CH4O3S/c17-15(18)12-5-2-10(3-6-12)1-4-11-7-8-13(16(19)20)9-14(11)21;2*1-5(2,3)4/h1-9,21H,(H3,17,18)(H3,19,20);2*1H3,(H,2,3,4)/b4-1+;;
• InChI key: YGNSQKCULHSJDC-HFPMQDOPSA-N

Description

General description

Hydroxystilbamidine bis (methanesulfonate), also known as Fluoro-Gold, is a retrograde fluorescent tracer. Chemically, Hydroxystilbamidine is a weak base and can cross cell membranes in its uncharged form.

A few properties of Hydroxystilbamidine bis (methanesulfonate) are:

• Intense Fluorescence.
• Extensive filling of dendrites.
• High Resistance to fading.
• No uptake by undamaged fibers.
• No diffusion from labelled cells.
• Highly compatible with other neuro-histochemical techniques.

Application

Hydroxystilbamidine bis (methanesulfonate) or Fluoro-Gold (FG) is used to label neurons and investigate the early effects of hearing loss. It is used to study morphological features of extensive axonal projections within the CNS by labelling the cells.

Hydroxystilbamidine bis(methanesulfonate), a fluorescent retrograde tracer (axonal transport), is used for neural mapping in microanatomical research.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves