Solute carrier family 22 member 17, also known as 24p3 receptor (24p3R) or Brain-type organic cation transporter or Lipocalin-2 receptor or Neutrophil gelatinase-associated lipocalin receptor (NgalR), and encoded by the gene name SLC22A17 or BOCT or BOIT, is a family of organic anion and cation transporters (OATs, OCTs, OCTNs) that are expressed in brain. Each contain 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways such as uniporters that mediate facilitated diffusion in either direction (OCTs), as anion exchangers (OAT1, OAT3 and URAT1), and as Na(+)/l-carnitine cotransporter (OCTN2). Slc22 family members participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart. Mutations in the Slc22 family may cause specific diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may change drug absorption or excretion. Recent studies show the expression of Slc22A17 as receptor for Lipocalin 2 is relatively high in hematopoietic stem cells.
Immunogen
KLH-conjugated synthetic peptide corresponding to the C-terminus of human Slc22A17.
Application
Anti-Slc22A17 Antibody is an antibody against Slc22A17 for use in western blotting & immunofluorescence.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected Slc22A17 in rat kidney tissue.
Quality
Evaluated by Western Blotting in SK-N-SH cell lysate with and without blocking peptide.
Western Blotting Analysis: 1 μg/mL of this antibody detected Slc22A17 in SK-N-SH cell lysate with and without blocking peptide.
Target description
~60 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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