5.04467

L-CCG-I

• Synonym(s): L-CCG-I
• Empirical Formula (Hill Notation): C₆H₉NO₄
• CAS Number: 117857-93-9
• Molecular Weight: 159.14
• UNSPSC Code: 12352200

Properties

• Assay: ≥97% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: aqueous base: soluble
• storage temp.: 2-8°C
• InChI: 1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3-,4-/m0/s1
• InChI key: GZOVEPYOCJWRFC-HZLVTQRSSA-N

Description

General description

A potent agonist for group II metabotropic glutamate receptors (EC₅₀ = 0.49 µM and 0.44 µM for mGlu₂ and mGlu₃, respectively). Higher level of activity than glutamate or (±)-trans-ACPD. Widely used in studies related to neurotransmissions mediated via group II mGlu receptors.

Biochem/physiol Actions

Primary Target
mGlu₂ & mGlu₃

Warning

Toxicity: Standard Handling (A)

Other Notes

Shinozaki, H., et al. 1989. Br. J. Pharmacol.98, 1213.
Hayashi, Y., et al. 1992. Br. J. Pharmacol.107, 539.
Nakanishi,S. 1992. Science.258, 597.
Watkins, J., et al. 1994. Trends Pharmacol Sci.15, 333.
Schoepp, D.D., et al. 1999. Neuropharmacology.38, 1431.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable