Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

495455

Sigma-Aldrich

Oligomycin

≥90% (mixture of A, B, and C isomers, HPLC), powder, Antibiotic, Calbiochem

Synonym(s):

Oligomycin

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C45H74O11
CAS Number:
1404-19-9
Molecular Weight:
791.06
MDL number:
MFCD01779388
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Product Name

Oligomycin, A mixture of A, B, and C isomers.

Quality Level

100

Assay

≥90% (mixture of A, B, and C isomers, HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

shipped in

ambient

storage temp.

−20°C

InChI

1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15-,21-18+

InChI key

MNULEGDCPYONBU-ZUSSGZTJSA-N

General description

A mixture of A, B, and C isomers. A macrolide antibiotic that inhibits membrane-bound mitochondrial ATP synthase, preventing phosphoryl group transfer. Induces apoptosis in cultured human lymphoblastoid and other mammalian cells.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Membrane-bound mitochondrial ATPase (F1)
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Wolvetang, E.J., et al. 1994. FEBS Lett.339, 40.
Amoroso, S., et al. 1993. J. Pharmacol. Exp. Ther.264, 515.
Brustovetsky, N.N., et al. 1993. FEBS Lett.315, 233.
Nagamune, H., et al. 1993. Biochim. Biophys. Acta1141, 231.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Birte Plitzko et al.
Bio-protocol, 8(10), e2850-e2850 (2018-05-20)
Mammalian cells generate ATP by mitochondrial (oxidative phosphorylation) and non-mitochondrial (glycolysis) metabolism. Cancer cells are known to reprogram their metabolism using different strategies to meet energetic and anabolic needs ( Koppenol et al., 2011 ; Zheng, 2012). Additionally, each cancer
Shuo Wan et al.
Frontiers in immunology, 12, 685984-685984 (2021-08-10)
Angiostrongylus cantonensis (AC), which parasitizes in the brain of the non-permissive host, such as mouse and human, is an etiologic agent of eosinophilic meningitis. Excretory-secretory (ES) products play an important role in the interaction between parasites and hosts' immune responses.
Thomas A Ryan et al.
The EMBO journal, 39(11), e102539-e102539 (2020-04-21)
Multiple mitochondrial quality control pathways exist to maintain the health of mitochondria and ensure cell homeostasis. Here, we investigate the role of the endosomal adaptor Tollip during the mitochondrial stress response and identify its interaction and colocalisation with the Parkinson's
Chunxin Wang
Current protocols in cell biology, 86(1), e99-e99 (2019-12-27)
Mitophagy is a selective autophagy process that specifically removes damaged mitochondria via general autophagy. The two major recessive Parkinson's disease genes PINK1 and Parkin play essential roles in mitophagy initiation, increasing the interest in mitophagy in both basic and translational
Pengcheng Zhang et al.
iScience, 25(1), 103709-103709 (2022-01-25)
SIRT1 is a metabolic sensor regulating energy homeostasis. The present study revealed that mice with selective overexpression of human SIRT1 in adipose tissue (Adipo-SIRT1) were protected from high-fat diet (HFD)-induced metabolic abnormalities. Adipose SIRT1 was enriched at mitochondria-ER contacts (MERCs)
View All Related Papers

Questions

1–2 of 2 Questions  

  1. Could you provide information on the proportions or ratio of Oligomycin A, B, and C in this mixture? Additionally, are the proportions consistent between lots?

    1 answer

    1. The isomer ratio of product 495455 has not been determined. It is known that the total (A+B+C) is greater than or equal to 90 percent.

      Helpful?

  2. As for the oligomycin(495455),what solvent can I use to dissolve it in order to preserve it as long as possible?

    1 answer

    1. Oligomycin is soluble in DMSO at 50 mg/mL, in ethanol at 250 mg/mL, and in acetone at 50 mg/mL. The solution is stable for at least a week at 0-4 °C and for several months when stored frozen in aliquots at -20 °C.

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service