344037

cFMS Receptor Inhibitor II - CAS 959860-85-6 - Calbiochem

The cFMS Receptor Inhibitor II, also referenced under CAS 959860-85-6, controls the biological activity of cFMS. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): cFMS Receptor Inhibitor II - CAS 959860-85-6 - Calbiochem, 4-(3,4-Dimethylanilino)-7-(4-pyridyl)quinoline-3-carboxamide, CSF-1 Receptor Inhibitor II
• Empirical Formula (Hill Notation): C₂₃H₂₀N₄O
• CAS Number: 959860-85-6
• Molecular Weight: 368.43
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 25 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Description

General description

A cell-permeable anilinoquinoline compound that acts as a potent, active site-targeting inhibitor of MCSF receptor/cFMS (IC₅₀ = 80 nM). Although equally potent as cFMS Receptor Inhibitor III (Cat. No. 344038) in inhibiting the cFMS-dependent growth of M-NSF-60 cells (IC₅₀ = 0.1 µM), this inhibitor is much more selective against cFMS-independent growth of NSO cells (IC₅₀ >50 µM).

A cell-permeable anilinoquinoline compound that acts as a potent, active site-targeting inhibitor of MCSF receptor/cFMS (IC₅₀ = 80 nM). Although equally potent as cFMS Receptor Inhibitor III (Cat. No. 344038) in inhibiting the cFMS-dependent growth of M-NSF-60 cells (IC₅₀ = 0.1 µM), this inhibitor is much more selective against cFMS-independent growth of NSO cells (IC₅₀ >50 µM).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Smalley, T.L. Jr., et al. 2007. Bioorg. Med. Chem. Lett.17, 6257.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable