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09-274

Sigma-Aldrich

Anti-PEAK1 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

NKF3 kinase family member, Sugen kinase 269

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

technique(s)

western blot: suitable

NCBI accession no.

NM_024776.2

UniProt accession no.

Q9H792

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PEAK1(79834)

General description

PEAK1 belongs to the protein kinase superfamily. PEAK1 is also called Tyrosine-protein kinase SgK269 and Sugen kinase 269. It contains a divergent and possibly inactive eukaryotic protein kinase domain. It has one human paralog, known as SgK223 or pragmin. These two constitute the NKF3 subfamily of protein kinases, found in vertebrates and echinoderms.

Specificity

Other species have not been tested.

Immunogen

Epitope: 1511-1660 aa
Recombinant Protein, aa: 1511-1660. Homology: 100% human and chimp; 96% pig and horse; 90% mouse; 88% rat

Application

This Anti-PEAK1 Antibody is validated for use in WB for the detection of PEAK1.

Quality

Routinely evaluated by Western Blot on FG Nonstim /Nonstrvd lysate.

Target description

250 kDa

Analysis Note

Control
FG Nonstim /Nonstrvd lysate

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Exosome-delivered circSATB2 targets the miR-330-5p/PEAK1 axis to regulate proliferation, migration and invasion of lung cancer cells.
Zhu, et al.
Thoracic cancer, 13, 3007-3017 (2023)
Ken Fujimura et al.
Cancer research, 78(6), 1444-1456 (2018-01-13)
There remains intense interest in tractable approaches to target or silence the KRAS oncoprotein as a rational therapeutic strategy to attack pancreatic ductal adenocarcinoma (PDAC) and other cancers that overexpress it. Here we provide evidence that accumulation of the KRAS
Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma.
Aguilera, KY; Rivera, LB; Hur, H; Carbon, JG; Toombs, JE; Goldstein, CD; Dellinger et al.
Cancer Research null
Kristina Y Aguilera et al.
Molecular cancer therapeutics, 16(11), 2473-2485 (2017-09-03)
The extracellular matrix (ECM), a principal component of pancreatic ductal adenocarcinoma (PDA), is rich in fibrillar collagens that facilitate tumor cell survival and chemoresistance. Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that specifically binds fibrillar collagens and

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