675725
4-Bromo-1-butyne
97%
Synonym(s):
1-Bromo-3-butyne
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About This Item
Empirical Formula (Hill Notation):
C4H5Br
CAS Number:
Molecular Weight:
132.99
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
97%
refractive index
n20/D 1.481
density
1.417 g/mL at 25 °C
SMILES string
BrCCC#C
InChI
1S/C4H5Br/c1-2-3-4-5/h1H,3-4H2
InChI key
XLYOGWXIKVUXCL-UHFFFAOYSA-N
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General description
4-Bromo-1-butyne is commonly used as a reactant. It serves as a source of alkyl halides for the introduction of bromo functionality into the molecule.
Application
4-Bromo-1-butyne is used as a reactant in the synthesis of:
- Macrocycles by cobalt-mediated [2+2+2] co-cyclotrimerization.
- 2,4,5-trisubstituted oxazoles by a gold-catalyzed formal [3+2] cycloaddition.
- Intramolecular 1,3-dipolar cycloaddition to synthesize 1,3,4-oxadiazoles.
- Lactones bearing alkynes for reductive cyclization in the preparation of azulene derivatives.
- Substituted α-pyrones by gold-catalyzed coupling reactions.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Flam. Liq. 3 - Skin Sens. 1
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
75.0 °F
Flash Point(C)
23.9 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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