393711

2′,3′-Dideoxy-3′-fluorouridine

95%

• Synonym(s): 3′-Fluoro-2′,3′-dideoxyuridine
• Empirical Formula (Hill Notation): C₉H₁₁FN₂O₄
• CAS Number: 41107-56-6
• Molecular Weight: 230.19
• Beilstein: 6064366
• EC Number: 415-360-8
• MDL number: MFCD00192015
• UNSPSC Code: 12352100
• PubChem Substance ID: 24864537
• NACRES: NA.22

Properties

• Assay: 95%
• optical activity: [α]20/D +10.5°, c = 0.5 in 1 M NaOH
• mp: 184-188 °C (lit.)
• SMILES string: OC[C@H]1O[C@H](C[C@@H]1F)N2C=CC(=O)NC2=O
• InChI: 1S/C9H11FN2O4/c10-5-3-8(16-6(5)4-13)12-2-1-7(14)11-9(12)15/h1-2,5-6,8,13H,3-4H2,(H,11,14,15)/t5-,6+,8+/m0/s1
• InChI key: BKIUEHLYJFLWPK-SHYZEUOFSA-N

Description

General description

2′,3′-Dideoxy-3′-fluorouridine (3′-fluoro-2′,3′-dideoxyuridine, FddUrd) is a fluorinated pyrimidine nucleoside analog of uridine. It has been studied extensively for its potential use as an antiviral agent against HIV.

Application

2′,3′-Dideoxy-3′-fluorouridine can be used as a starting material in the synthesis of:

• 3′-fluoro 2′,3′-dideoxynucleoside analogs for in vitro antiviral activity studies.
• 3′-fluoro deoxyuridine monophosphate analogs as potential anti parasites.

Safety Information

• Pictograms: GHS08
• Signal Word: Warning
• Hazard Statements: H341
• Precautionary Statements: P281
• Hazard Classifications: Muta. 2
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves