264423
2,5-Difluorobenzyl bromide
98%
Synonym(s):
α-Bromo-2,5-difluorotoluene
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About This Item
Linear Formula:
F2C6H3CH2Br
CAS Number:
Molecular Weight:
207.02
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
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Assay
98%
refractive index
n20/D 1.526 (lit.)
density
1.609 g/mL at 25 °C (lit.)
SMILES string
Fc1ccc(F)c(CBr)c1
InChI
1S/C7H5BrF2/c8-4-5-3-6(9)1-2-7(5)10/h1-3H,4H2
InChI key
ONWGSWNHQZYCFK-UHFFFAOYSA-N
Application
2,5-Difluorobenzyl bromide has been used in the synthesis of:
- novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived γ-secretase inhibitors, for the potential treatment of Alzheimer′s disease
- sulfonamide, amide and acyclic amine derivatives
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Flam. Liq. 2 - Skin Corr. 1B
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
60.8 °F - closed cup
Flash Point(C)
16 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Martin Teall et al.
Bioorganic & medicinal chemistry letters, 15(10), 2685-2688 (2005-05-03)
The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described.
Ping Chen et al.
Bioorganic & medicinal chemistry letters, 21(6), 1880-1886 (2011-02-16)
A series of 4-amino cyclohexanes and 4-substituted piperidines were prepared and evaluated for inhibition of DPP-4. Analog 20q displayed both good DPP-4 potency and selectivity against other proteases, while derivative 20k displayed long half life and modest oral bioavailability in
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