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Assay
99%
form
liquid
refractive index
n20/D 1.409 (lit.)
bp
129-130 °C (lit.)
density
1.092 g/mL at 25 °C (lit.)
SMILES string
COC1OCCO1
InChI
1S/C4H8O3/c1-5-4-6-2-3-7-4/h4H,2-3H2,1H3
InChI key
VRAYTNFBRROPJU-UHFFFAOYSA-N
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Application
2-Methoxy-1,3-dioxolane was used in the synthesis of :
- [4,5-bis(hydroxymethyl)-1,3-dioxolan-2-yl]nucleosides, potential inhibitors of HIV
- diastereoisomeric cyclic acetals
Signal Word
Warning
Hazard Statements
Hazard Classifications
Flam. Liq. 3
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
93.2 °F - closed cup
Flash Point(C)
34 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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The Journal of organic chemistry, 61(11), 3599-3603 (1996-05-31)
The synthesis of 1,3-dioxolan-2-ylnucleosides and related chemistry is described. We have shown that 2-methoxy-1,3-dioxolane (6) reacts with silylated thymine and trimethylsilyl triflate to give the acyclic formate ester 1-[2-(formyloxy)ethyl]thymine (8) rather than 1-(1,3-dioxolan-2-yl)thymine (7). A tentative mechanism which could explain
Synthesis of highly substituted 2, 6-anti-configured tetrahydropyrans. First steps towards an efficient access to amphidinol 3 ring system.
Tetrahedron Letters, 46(23), 4005-4009 (2005)
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