F13A1
coagulation factor XIII, A1 polypeptide
Synonyms:
F13A
Species:
Human F13A1 (2162), Mouse F13a1 (74145), Rat F13a1 (60327), naked mole-rat F13a1 (101715346), chicken F13A1 (395420), dog F13A1 (478711), domestic cat F13A1 (101080534), Horse F13A1 (100060428), cow F13A1 (617881), sheep F13A1 (101108612)
UniProtKB ID:
Gene ID:
- Human(2162) Summary: This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
- Mouse(74145) coagulation factor XIII, A1 subunit
- Rat(60327) coagulation factor XIII, A1 polypeptide
- naked mole-rat(101715346) coagulation factor XIII, A1 polypeptide
- chicken(395420) coagulation factor XIII, A1 polypeptide
- dog(478711) coagulation factor XIII, A1 polypeptide
- domestic cat(101080534) coagulation factor XIII, A1 polypeptide
- Horse(100060428) coagulation factor XIII, A1 polypeptide
- cow(617881) coagulation factor XIII, A1 polypeptide
- sheep(101108612) coagulation factor XIII, A1 polypeptide
- domestic guinea pig(100719684) coagulation factor XIII, A1 polypeptide
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Antibodies
Product Number
Description
Species Reactivity
Application
Factor XIIIa (AC-1A1) Mouse Monoclonal Antibody, ,
Species Reactivity
human
Application
immunohistochemistry
Anti-F13A1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-F13A1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Monoclonal Anti-F13A1 antibody produced in mouse, clone 4G5, ascites fluid,
Species Reactivity
human
Application
ELISA
western blot
western blot
Monoclonal Anti-F13A1 antibody produced in mouse, clone M1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
proximity ligation assay
proximity ligation assay