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1478505

USP

Omeprazole

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, Antra, Losec

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About This Item

Empirical Formula (Hill Notation):
C17H19N3O3S
CAS Number:
Molecular Weight:
345.42
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

omeprazole

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C

InChI

1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)

InChI key

SUBDBMMJDZJVOS-UHFFFAOYSA-N

Gene Information

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.Omeprazole is a benzimidazole derivative, which exhibits antisecretory and antiulcer properties. It is a drug with selective and irreversible proton pump inhibition activity, widely used in the treatment of duodenal, gastric ulcers, reflux oesophagitis, and against other acid-related diseases.

Application

Omeprazole USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Esomeprazole Magnesium
  • Esomeprazole Magnesium Delayed-Release Capsules
  • Esomeprazole Strontium
  • Omeprazole
  • Omeprazole Delayed-Release Capsules
  • Omeprazole Magnesium

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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Pictograms

Exclamation markEnvironment

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Development and validation of a RP-HPLC method for the quantification of omeprazole in pharmaceutical dosage form
Kayesh R, et al.
Journal of Scientific Research, 5(2), 335-342 (2013)
Determination of omeprazole in bulk and injectable preparations by liquid chromatography
Schubert A, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 86(3), 501-504 (2003)
Extractive spectrophotometric determination of omeprazole in pharmaceutical preparations
Bhandage A, et al.
Tropical Journal of Pharmaceutical Research, 8(5) (2009)
Analytical method development and validation for the determination of omeprazole and aspirin using reverse phase hplc method in bulk and dosage form
Vani, R and Sunitha, M
Journal of Pharmacological Sciences, 2(4), 25-29 (2017)
The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: implications for coadministration with clopidogrel
Ogilvie BW, et al.
Drug Metabolism and Disposition, 39(11), 2020-2033 (2011)

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