X2628

Xestospongin C

IP3 receptor Inhibitor, film

• Synonym(s): XeC
• Linear Formula: C₂₈ H₅₀ N₂ O₂
• CAS Number: 88903-69-9
• Molecular Weight: 446.71
• UNSPSC Code: 12352200
• PubChem Substance ID: 24902138
• NACRES: NA.77
• MDL number: MFCD01862629
• Form: film

Properties

• Product Name: Xestospongin C, film
• form: film
• Quality Segment: 100
• color: colorless
• solubility: DMSO: soluble
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H][C@@]12CCCCCC[C@@]3([H])CCCN4CC[C@@]([H])(CCCCCC[C@]5([H])CCCN(CC1)[C@@]5([H])O2)O[C@@]34[H]
• InChI: 1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24+,25-,26-,27+,28+/m1/s1
• InChI key: PQYOPBRFUUEHRC-HCKQMYSWSA-N

Description

General description

Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge.

Biochem/physiol Actions

Xestospongin C is a potent, reversible and membrane-permeable blocker of IP₃-mediated Ca²⁺ release (IC₅₀=358 nM).

Xestospongin C is a selective, reversible and membrane-permeable inhibitor of IP₃ receptor. Reversibly blocks bradykinin- and carbamylcholine- Ca²⁺ efflux from the endoplasmic reticulum stores.

Features and Benefits

This compound is featured on the InsP3/Ryanodine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Package under nitrogen, tightly sealed.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)