X2502

Xanthine sodium salt

≥99%

• Synonym(s): 2,6-Dihydroxypurine
• Empirical Formula (Hill Notation): C₅H₃N₄NaO₂
• CAS Number: 1196-43-6
• Molecular Weight: 174.09
• NACRES: NA.51
• PubChem Substance ID: 24902137
• UNSPSC Code: 41106305
• MDL number: MFCD00069699
• Assay: ≥99%
• Biological source: synthetic (organic)
• Form: powder
• Solubility: dilute NaOH: soluble, clear to slightly hazy

Properties

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥99%
• form: powder
• impurities: ≤4% total solvent
• solubility: dilute NaOH: soluble, clear to slightly hazy
• SMILES string: [Na].O=C1NC(=O)c2[nH]cnc2N1
• InChI: 1S/C5H4N4O2.Na.H/c10-4-2-3(7-1-6-2)8-5(11)9-4;;/h1H,(H3,6,7,8,9,10,11);;
• InChI key: JAZQMXVZANZJSO-UHFFFAOYSA-N

Description

General description

Xanthine is an intermediate of purine nucleotide metabolism. It is found in most body tissues and fluids. Xanthine derivatives are present in coffee, tea, and chocolate.

Application

Xanthine sodium salt has been used as a component of substrate solution for xanthine oxidase during superoxide dismutase (SOD) assay. It has also been used as a supplement in a special-conditioned medium to culture Swiss 3T3 fibroblasts stably transfected with tetracycline (tet)-controlled transactivator and transactivator-controlled tissue transglutaminase cDNA [39] constructs (clone TG3).

Biochem/physiol Actions

Xanthine acts as a substrate for xanthine oxidase. It elevates cellular cyclic AMP levels by preventing its breakdown and metabolism by inhibition of tissue phosphodiesterases. Xanthine also exhibits anti-inflammatory properties either by the release of anti-inflammatory cytokines or gene transcription regulation or histone deacetylase activation. All these properties of xanthine aid in the relaxation of smooth muscles of the bronchial tree.

Safety Information

• pictograms: GHS08
• signalword: Warning
• hcodes: H371
• pcodes: P260 - P264 - P270 - P308 + P311 - P405 - P501
• Hazard Classifications: STOT SE 2
• target_organs: Eyes,Central nervous system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves