W0769

Wogonin hydrate

≥98% (HPLC), solid

• Synonym(s): 5,7-Dihydroxy-8-methoxyflavone
• Empirical Formula (Hill Notation): C₁₆H₁₂O₅ · xH₂O
• CAS Number: 632-85-9
• Molecular Weight: 284.26 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 329830424
• UNSPSC Code: 12352200
• MDL number: MFCD12828871
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: ≥20 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.COc1c(O)cc(O)c2C(=O)C=C(Oc12)c3ccccc3
• InChI: 1S/C16H12O5.H2O/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9;/h2-8,17,19H,1H3;1H2
• InChI key: XLCSETHCROERAU-UHFFFAOYSA-N

Description

General description

Wogonin is a flavonoid component of Scutellaria baicalensis Georgi roots.

Application

Wogonin hydrate has been used to enhance the cytotoxicity of oxaliplatin in gastric cancer cells and zebrafish xenograft model and to test its effect on the expression and secretion of adiponectin in mature 3T3-L1 adipocytes.

Biochem/physiol Actions

Wogonin is an anti-inflammatory agent and COX-2 inhibitor, which inhibits the induction of both iNOS and COX-2.

Wogonin is an anti-inflammatory agent and COX-2 inhibitor, which inhibits the induction of both iNOS and COX-2. Wogonin inhibits COX-2 (IC₅₀ = 46 μM) without affecting COX-1. Wogonin inhibits iNOS induction and thus inhibts activation-induced C6 glial cell death. Specifically, Wogonin inhibits NF-kappaB-mediated iNOS induction.

Wogonin co-treatment enhances apoptosis and antitumor potential of chemotherapeutic drug, oxaliplatin in gastric cancer cells. It also improves the efficacy of fluorouracil and paclitaxel. Wogonin anti-oxidative functionality may be useful in treating neurodegenerative and inflammatory diseases.

Features and Benefits

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)