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Tropicamide

Name: Tropicamide
Brand: SIGMA

Muscarinic receptor antagonist, solid

Synonym(s):

N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide, Ro 1-7683

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₀N₂O₂

CAS Number:

1508-75-4

Molecular Weight:

284.35

NACRES:

NA.77

PubChem Substance ID:

24277879

UNSPSC Code:

12352200

EC Number:

216-140-2

MDL number:

MFCD00058580

Form:

solid

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Properties

Product Name

Tropicamide, solid

form

solid

Quality Segment

100

color

white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 mg/mL, ethanol: 5.6 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

CCN(Cc1ccncc1)C(=O)C(CO)c2ccccc2

InChI

1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3

InChI key

BGDKAVGWHJFAGW-UHFFFAOYSA-N

Gene Information

human ... CHRM3(1131), CHRM4(1132)

Description

Application

Tropicamide has been used for studying the regulation of fragile X behavior in male mice[1]. 1% tropicamide has also been used for dilating mice pupils[2].

Biochem/physiol Actions

M₄ muscarinic acetylcholine receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

Tropicamide is soluble in 45% (w/v) aqueous 2-hydroxypropyl-beta-cyclodextrin (4.3 mg/mL) and ethanol (5.6 mg/mL).

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This Item	U103	Y0001316	P4532
Sigma-Aldrich T9778 Tropicamide	Sigma-Aldrich U103 U-69593	Y0001316 Tropicamide for peak identification	Sigma-Aldrich P4532 (−)-N⁶-(2-Phenylisopropyl)adenosine
form solid	form solid	form -	form solid
Quality Level 100	Quality Level 100	Quality Level -	Quality Level 200
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 mg/mL, H₂O: insoluble, ethanol: 5.6 mg/mL	solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 10 mg/mL, 0.1 M HCl: >40 mg/mL, ethanol: >40 mg/mL, 0.1 M NaOH: insoluble, H₂O: insoluble	solubility -	solubility H₂O: slightly soluble 0.3 mg/mL (Solutions may be stored for several days at 4°C.), 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.6 mg/mL (Solutions may be stored for several days at 4°C.)
color white	color white	color -	color white
Gene Information human ... CHRM3(1131), CHRM4(1132)	Gene Information human ... OPRD1(4985), OPRK1(4986), OPRM1(4988) mouse ... Oprk1(18387) rat ... Oprd1(24613), Oprk1(29335), Oprm1(25601)	Gene Information human ... CHRM3(1131)	Gene Information human ... ADORA1(134)

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pictograms

GHS07

signalword

Warning

hcodes

H302 + H312 + H332,H315,H317,H319,H335

pcodes

P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c