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(+)-α-Tocopherol acetate

Name: (+)-α-Tocopherol acetate
Brand: SIGMA

BioReagent, suitable for insect cell culture, ~1360 IU/g

Synonym(s):

Vitamin E acetate

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About This Item

Empirical Formula (Hill Notation):

C₃₁H₅₂O₃

CAS Number:

58-95-7

Molecular Weight:

472.74

PubChem Substance ID:

24899940

eCl@ss:

34058007

UNSPSC Code:

12352205

NACRES:

NA.75

EC Number:

200-405-4

MDL number:

MFCD00072052

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Properties

biological source

plant

Quality Segment

200

description

Synthesized from natural α-tocopherol

product line

BioReagent

form

liquid (or semi-solid)

specific activity

~1360 IU/g

mol wt

M_w 472.74 g/mol

purified by

crystallization

technique(s)

cell culture | insect: suitable

color

white to yellow

solubility

chloroform: soluble 50 mg/mL, clear, colorless to yellow

storage temp.

room temp

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

InChI key

ZAKOWWREFLAJOT-CEFNRUSXSA-N

Description

General description

α-Tocopherol acetate is a semisynthetic acetate ester of naturally occurring α-tocopherol.

Application

(+)-α-Tocopherol acetate has been used:

as a supplement in the human embryonic kidney cells (HEK 293) to assess its impact on cell growth[1]
as a component of Dulbecco′s Modified Eagle Medium/Nutrient Mixture F-12 (DMEM/F12) for immortalized chondrocyte cell line[2]
as a component of serum-free medium for human colon tissue organ culture[3]
to test its antioxidant effects on cow articular chondrocytes[4]

Use in insect cell culture applications as an antioxidant.

Biochem/physiol Actions

α-Tocopherol acetate or vitamin E-acetate has antioxidant properties and reduces lipid peroxidation. However, vitamin E acetate on pyrolysis leads to the generation of carcinogens like alkenes and benzenes.[5]

Disclaimer

Since the M.P. is about 25 °C this preparation is usually an oil. Does not air oxidize.

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This Item	T3001	29992	T1539
Sigma-Aldrich T1157 (+)-α-Tocopherol acetate	Sigma-Aldrich T3001 (+)-α-Tocopherol acetate	Sigma-Aldrich 29992 DL-α-Tocopherol acetate	Sigma-Aldrich T1539 (+)-α-Tocopherol
technique(s) cell culture \| insect: suitable	technique(s) -	technique(s) -	technique(s) cell culture \| insect: suitable
biological source plant	biological source plant	biological source synthetic	biological source vegetable oil
form liquid (or semi-solid)	form oil or semi-solid	form liquid	form liquid (≥0.88M based on potency, density and molecular wt.)
storage temp. room temp	storage temp. room temp	storage temp. 2-8°C	storage temp. 2-8°C
solubility chloroform: soluble 50 mg/mL, clear, colorless to yellow	solubility -	solubility -	solubility chloroform: soluble 0.1 mL/mL, clear, faintly yellow to yellow
color white to yellow	color yellow	color -	color yellow-orange

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hcodes

H413

pcodes

P273 - P501

Hazard Classifications

Aquatic Chronic 4

Storage Class

10 - Combustible liquids

wgk

WGK 1

ppe

Eyeshields, Gloves

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