SML3736
Hypoxia probe 2
95% (UPLC)
Synonym(s):
5’-Methoxy-1’,2’-dimethyl-3-(1-((3-oxo-3H-phenoxazin-7-yl)oxy)ethyl)-1H-indole-4’,7’-dione
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About This Item
Empirical Formula (Hill Notation):
C25H20N2O6
Molecular Weight:
444.44
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
95% (UPLC)
form
powder
storage condition
protect from light
color
, Faint orange to red
solubility
DMSO: 2 mg/mL, clear (Warmed)
shipped in
wet ice
storage temp.
-10 to -25°C
Biochem/physiol Actions
Hypoxia probe 2 is a resorufin-based non-fluorescent hypoxia probe that undergoes cytochrome P450 reductase (PH51)-catalyzed reduction to yield the fluorescent reporter resorufin (ex 545 nm, em 582 nm) in conditions of 4% O2 and lower, allowing imaging hypoxia levels similar to those detected by pimonidazole without the use of antibodies. When employed together with Tokyo green-based hypoxia probe 4 (Tokyo green ex 480 nm, em 515 nm), the probe pair allows the simultaneous (two-color) imaging of different hypoxia levels in living cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Two Color Imaging of Different Hypoxia Levels in Cancer Cells.
Journal of the American Chemical Society, 145(4), 2572-2583 (2023)
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