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SML3416

Hinokiflavone

≥97% (HPLC)

Synonym(s):

4′,5,5′′,7,7′′-Pentahydroxy-4′′′,6-oxydi-flavone (8CI), 6-[4-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

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About This Item

Empirical Formula (Hill Notation):
C30H18O10
CAS Number:
Molecular Weight:
538.46
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
desiccated
Pricing and availability is not currently available.
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Quality Segment

assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

[o]1c2c([c](cc1c6ccc(cc6)O)=O)c(c(c(c2)O)Oc3ccc(cc3)c4[o]c5c([c](c4)=O)c(cc(c5)O)O)O

InChI

1S/C30H18O10/c31-16-5-1-14(2-6-16)24-12-21(35)28-26(40-24)13-22(36)30(29(28)37)38-18-7-3-15(4-8-18)23-11-20(34)27-19(33)9-17(32)10-25(27)39-23/h1-13,31-33,36-37H

InChI key

WTDHMFBJQJSTMH-UHFFFAOYSA-N

Biochem/physiol Actions

Hinokiflavone is a plant biflavone that exhibit potent anticancer, hepatoprotective, antibacterial, antiviral, and anti-inflammatory activities. Hinokiflavone induces apoptosis and cell cycle arrest, and blocks migration and invasion of melanoma cells. It is a potent inhibitor of dengue 2 virus RNA-dependent RNA polymerase (DV-NS5 RdRp). Hinokiflavone is a modulator of pre-mRNA splicing in cells. It increases SUMOylation of a subset of spliceosome proteins by inhibiting SENP1 protease activity. It induces apoptosis in esophageal squamous cell carcinoma (ESCC) through regulation of PI3K/AKT/mTOR pathway.
Modulator of pre-mRNA splicing in cells; potent inhibitor of dengue 2 virus RNA-dependent RNA polymerase (DV-NS5 RdRp)

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This Item
SML0582PHL83840PHL82569
description

≥97% (HPLC)

description

≥98% (HPLC)

description

phyproof® Reference Substance

description

phyproof® Reference Substance

form

powder

form

powder

form

-

form

-

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥85.0% (HPLC)

assay

≥95.0% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

-

storage temp.

-10 to -25°C

storage temp.

−20°C

storage temp.

-

storage temp.

-

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

-

solubility

-

storage condition

desiccated

storage condition

desiccated

storage condition

-

storage condition

-


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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