SML2840

AZD2066

≥98% (HPLC)

• Synonym(s): 4-[5-[(1R)-1-[5-(3-Chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4H-1,2,4-triazol-3-yl]pyridine, AZD 2066
• Empirical Formula (Hill Notation): C₁₉H₁₆ClN₅O₂
• CAS Number: 934282-55-0
• Molecular Weight: 381.82
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: Clc1cc(ccc1)c2[o]nc(c2)[C@H](Oc3[n](c(nn3)c4ccncc4)C)C
• InChI: 1S/C19H16ClN5O2/c1-12(16-11-17(27-24-16)14-4-3-5-15(20)10-14)26-19-23-22-18(25(19)2)13-6-8-21-9-7-13/h3-12H,1-2H3/t12-/m1/s1
• InChI key: SXWHYTICXCLKDG-GFCCVEGCSA-N

Description

Biochem/physiol Actions

AZD2066 is an orally bioavailable, brain penetrant, selective and potent negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGlu5). AZD2066 exhibited satisfactory efficacy in patients suffering from neuropathic pain with mechanical hypersensitivity.

orally bioavailable, brain penetrant, selective and potent negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGlu5)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable