SML2670

BAY-8002

≥98% (HPLC)

• Synonym(s): 2-(2-chloro-5-(phenylsulfonyl)benzamido)benzoic acid, 2-[[2-Chloro-5-(phenylsulfonyl)benzoyl]amino]-benzoic acid
• Empirical Formula (Hill Notation): C₂₀H₁₄ClNO₅S
• CAS Number: 724440-27-1
• Molecular Weight: 415.85
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD05157149
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [S](=O)(=O)(c2cc(c(cc2)Cl)C(=O)Nc3c(cccc3)C(=O)O)c1ccccc1
• InChI: 1S/C20H14ClNO5S/c21-17-11-10-14(28(26,27)13-6-2-1-3-7-13)12-16(17)19(23)22-18-9-5-4-8-15(18)20(24)25/h1-12H,(H,22,23)(H,24,25)
• InChI key: CLAUJSRBKSRTGQ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

BAY-8002 is an orally available, potent and selective inhibitor of lactate transporter MCT1 (monocarboxylate transporter 1; SLC16A1) that potently inhibits bidirectional lactate transport. BAY-8002 exhibits antiproliferative activity in numerous cancer cell lines. BAY-8002 induces accumulation of lactate and significantly inhibits tumor growth in mice model. It does not cause tumor regression.

orally available, potent and selective inhibitor of lactate transporter MCT1

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable