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SML2622

ABC1183

≥98% (HPLC)

Synonym(s):

4-(4-Amino-2-p-tolylamino-thiazole-5-carbonyl)-benzonitrile, 4-[[4-Amino-2-[(4-methylphenyl)amino]-5-thiazolyl]carbonyl]-benzonitrile

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About This Item

Empirical Formula (Hill Notation):
C18H14N4OS
CAS Number:
1042735-18-1
Molecular Weight:
334.39
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC1=C(C(C2=CC=C(C=C2)C#N)=O)SC(NC3=CC=C(C)C=C3)=N1

InChI

1S/C18H14N4OS/c1-11-2-8-14(9-3-11)21-18-22-17(20)16(24-18)15(23)13-6-4-12(10-19)5-7-13/h2-9H,20H2,1H3,(H,21,22)

InChI key

CUDLEXBIVZPJBU-UHFFFAOYSA-N

Biochem/physiol Actions

ABC1183 is an orally active, potent and selective inhibitor of GSK3 α/β and CDK9, which induces G2/M cell cycle arrest and apoptosis in cancer cells. Apparently ABC1183 suppresses tumor growth and inflammation-driven gastrointestinal disease symptoms due to down regulation of TNFα and IL-6 pro-inflammatory cytokines. It does not exhibit organ or hematological toxicities.
an orally active, potent and selective inhibitor of GSK3 α/β and CDK9

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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