SML1942

Drotaverine hydrochloride

≥95% (HPLC), powder, PDE inhibitor

• Synonym(s): 1-[(3,4-Diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, 3′,4′,6,7-Tetraethoxy-1-benzylidene-1,2,3,4-tetrahydroisoquinoline hydrochloride, Drotaverin hydrochloride, Tetraspasmin-Lefa
• Empirical Formula (Hill Notation): C₂₄H₃₁NO₄ · HCl
• CAS Number: 985-12-6
• Molecular Weight: 433.97
• NACRES: NA.77
• UNSPSC Code: 12352200
• MDL number: MFCD00347721
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Product Name: Drotaverine hydrochloride, ≥95% (HPLC)
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: CCOC1=CC=C(/C=C2C3=C(CCN/2)C=C(OCC)C(OCC)=C3)C=C1OCC.[H]Cl
• InChI: 1S/C24H31NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-10,13-16,25H,5-8,11-12H2,1-4H3;1H/b20-13-;
• InChI key: JBFLYOLJRKJYNV-MASIZSFYSA-N

Description

Biochem/physiol Actions

A PDE4-selective phosphodiesterase inhibitor and an L-type voltage-dependent calcium channel blocker with in vivo antispasmodic efficacy.

Drotaverine (Drotaverin) is an isoquinoline-based PDE4-selective phosphodiesterase (PDE) inhibitor and an L-type voltage-dependent (voltage-operated) calcium channel (L-VDCC or L-VOCC) blocker that exhibits in vivo antispasmodic efficacy without anticholinergic effects.

It is a benzylisoquinoline derivative. Drotaverine acts as a smooth muscle relaxant.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable