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SML1506

KY-05009

≥98% (HPLC)

Synonym(s):

5-(4-Methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide, 5-[(4-Methylbenzoyl)amino]-2-(phenylamino)-4-thiazolecarboxamide

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About This Item

Empirical Formula (Hill Notation):
C18H16N4O2S
CAS Number:
Molecular Weight:
352.41
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

light yellow to dark yellow

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC(C1=C(NC(C2=CC=C(C)C=C2)=O)SC(NC3=CC=CC=C3)=N1)=O

InChI

1S/C18H16N4O2S/c1-11-7-9-12(10-8-11)16(24)22-17-14(15(19)23)21-18(25-17)20-13-5-3-2-4-6-13/h2-10H,1H3,(H2,19,23)(H,20,21)(H,22,24)

InChI key

WCEDGRTWDSHZHF-UHFFFAOYSA-N

Biochem/physiol Actions

KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor that inhibits the epithelial-to-mesenchymal transition (EMT) in cancer cells.
KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor.
KY-05009 is also known as (5-(4-methylbenzamido)-2-(phenylamino) thiazole-4-carboxamide). It prevents the proliferation induced by interleukin-6 and promotes cell death by blocking Wnt signaling in multiple myeloma (MM) cells. KY-05009 is a novel aminothiazole, which possesses anti-cancer activity in human colorectal cancer cells. KY-05009 prevents migration and invasion stimulated by TGF-β1 (transforming growth factor beta 1).

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This Item
HPA012128HPA012297
description

≥98% (HPLC)

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

form

powder

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

assay

≥98% (HPLC)

assay

-

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 10 mg/mL, clear

solubility

-

solubility

-

color

light yellow to dark yellow

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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