SML0723

ML252

≥98% (HPLC)

• Synonym(s): (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide
• Empirical Formula (Hill Notation): C₂₀H₂₄N₂O
• CAS Number: 1392494-64-2
• Molecular Weight: 308.42
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: , light to dark purple
• solubility: DMSO: 25 mg/mL, clear
• storage temp.: 2-8°C

Description

Biochem/physiol Actions

ML252 is a potent, brain penetrant potassium channel Kv7.2 (KCNQ2) inhibitor with an IC₅₀ of 69 nM. ML252 is only slightly selective over KCNQ3 and KCNQ4 but is over 40-fold selective for KCNQ2 vs KCNQ1, unlike other KCNQ inbhibitors currently used. ML252 was also selective vs. >68 tested GPCRs, ion channels, and transporters. Potassium channel Kv7.2 has become a new target for Alzheimer′s Disease drug research because inhibiting it enhances acetylcholine release. SAR studies showed a small structural change from ethyl group to hydrogen resulted in a functional shift from antagonist to agonist activity (37, EC₅₀ of 170 nM), suggesting an interaction at a critical site for controlling KCNQ2 channel gating.

ML252 is a potent, brain penetrant potassium channel Kv7.2 (KCNQ2) inhibitor.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable