SCP0148

Furin Inhibitor II Peptide

≥95% (HPLC), lyophilized powder

• Synonym(s): Hexa-D-arginine amide
• Empirical Formula (Hill Notation): C₃₆H₇₅N₂₅O₆
• Molecular Weight: 954.14
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• Product Name: Furin Inhibitor II,
• assay: ≥95% (HPLC)
• form: lyophilized
• composition: Peptide Content, ≥48%
• storage condition: protect from light
• technique(s): protein extraction: suitable
• storage temp.: −20°C

Description

General description

Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family. It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes.

Application

Furin Inhibitor II has been used as a furin inhibitor:

• to study its effects on transforming growth factor β1 (TGF-β1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG).
• to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells.
• in furin cleavage assay.

Biochem/physiol Actions

Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein 4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteases and pro-β-nerve growth (pro-β-NGF) factor. Furin is also involved in cleaving transforming growth factor β1 (TGF-β1).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable