R8900

Ro 8-4304

solid

• Empirical Formula (Hill Notation): C₂₁H₂₃FN₂O₃ · HCl
• Molecular Weight: 406.88
• NACRES: NA.77
• PubChem Substance ID: 24277971
• UNSPSC Code: 12352200
• MDL number: MFCD03101333
• Form: solid

Properties

• form: solid
• Quality Segment: 100
• solubility: H₂O: ≤0.5 mg/mL
• originator: Roche
• storage temp.: 2-8°C
• SMILES string: Cl.NC(=O)c1ccc(OCCC(O)N2CCC(=CC2)c3ccc(F)cc3)cc1
• InChI: 1S/C21H23FN2O3.ClH/c22-18-5-1-15(2-6-18)16-9-12-24(13-10-16)20(25)11-14-27-19-7-3-17(4-8-19)21(23)26;/h1-9,20,25H,10-14H2,(H2,23,26);1H
• InChI key: NYFXHCMXYODFLP-UHFFFAOYSA-N
• Gene Information: human ... GRIN2B(2904)

Description

Biochem/physiol Actions

NR2B-selective, noncompetitive NMDA glutamate receptor antagonist

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves