P9256

Psychosine from bovine brain

lyophilized powder, ≥98% (HPLC)

• Synonym(s): 1-β-D-Galactosylsphingosine
• Empirical Formula (Hill Notation): C₂₄H₄₇NO₇
• CAS Number: 2238-90-6
• Molecular Weight: 461.63
• NACRES: NA.77
• PubChem Substance ID: 24899021
• UNSPSC Code: 12352211
• MDL number: MFCD00057505
• Assay: ≥98% (HPLC)
• Form: lyophilized powder

Properties

• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: lyophilized powder
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O
• InChI: 1S/C24H47NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h14-15,18-24,26-30H,2-13,16-17,25H2,1H3/b15-14+/t18-,19+,20+,21-,22-,23+,24+/m0/s1
• InChI key: HHJTWTPUPVQKNA-PIIMIWFASA-N

Description

Application

Psychosine has been used as a lipid in lipid-protein overlay binding assay.

Biochem/physiol Actions

Psychosine is a neurotoxic lysosphingolipid and a glycolipid precursor for the synthesis of cerebrosides. It is synthesized from galactosylceramide, phrenosin. Elevated psychosine levels are implicated in Krabbe disease. It mediates demyelination and consequently oligodendrocytes degeneration. Psychosine is also correlated to neurological disease, Globoid cell leukodystrophy (GLD), where in galactosylceramidase (GALC) enzyme deficiency leads to its accumulation.

Safety Information

• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves