P0122

Pifithrin-μ

≥97% (HPLC), solid

• Synonym(s): 2-Phenylethynesulfonamide, PFTμ
• Empirical Formula (Hill Notation): C₈H₇NO₂S
• CAS Number: 64984-31-2
• Molecular Weight: 181.21
• NACRES: NA.77
• PubChem Substance ID: 24724568
• UNSPSC Code: 12352200
• MDL number: MFCD00181531
• Assay: ≥97% (HPLC)
• Form: solid
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: solid
• storage condition: desiccated
• solubility: DMSO: soluble >10 mg/mL, clear, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: NS(=O)(=O)C#Cc1ccccc1
• InChI: 1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
• InChI key: ZZUZYEMRHCMVTB-UHFFFAOYSA-N

Description

Application

Pifithrin-μ has been used:

• to treat microglial cell line to analyse its neuroprotective effect on M1-like and M2-like phenotype
• as heat shock protein (HSP)-70 inhibitor, to treat transfected Marc-145 cells
• to inhibit heat shock cognate 70 (Hsc70) to elucidate heat shock chaperones mouse embryonic stem cells

Biochem/physiol Actions

Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins.

Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins. PFTμ rescues cells from lethal γ-irradiation-induced cell death. Because pifithrin-μ shuts down only the p53-mitochondrial pathway without affecting the transcriptional functions of p53, it is superior to pifithrin-α.

Pifithrin-μ(PFT-μ) has neuroprotective capabilities against cell death in a preclinical model of hypoxia-ischemia (HI)-induced neonatal encephalopathy. It inhibits nuclear factor-ΙB (NF-ΙB) pathway by inhibiting the interaction of molecular chaperone heat shock protein (HSP)-70 with its substrates.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves