The analytical standard version of this compound, 34037, is a 10ug/mL solution in acetonitrile. This product is also soluble in chloroform (9.80 - 10.20 mg/ml), methanol (10 mg/ml), ethanol (50 mM), and DMSO (100 mM). The choice of solvent would be best determined by the researcher.
O1877
Ochratoxin A
from Petromyces albertensis, ≥98% (HPLC), powder, mycotoxin
Ochratoxin A
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Synonym(s):
N-[(3R)-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L-phenylalanine
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About This Item
Empirical Formula (Hill Notation):
C20H18ClNO6
CAS Number:
Molecular Weight:
403.81
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
1301486
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Product Name
Ochratoxin A, from Petromyces albertensis, ≥98% (HPLC)
biological source
Petromyces albertensis
Quality Segment
assay
≥98% (HPLC)
form
powder
impurities
Benzene, free
solubility
ethanol: soluble
mode of action
enzyme | inhibits, protein synthesis | interferes
storage temp.
2-8°C
SMILES string
C[C@@H]1Cc2c(Cl)cc(c(O)c2C(=O)O1)C(=O)N[C@@H](Cc3ccccc3)C(O)=O
InChI
1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1
InChI key
RWQKHEORZBHNRI-BMIGLBTASA-N
Application
Ochratoxin A has been used as a mycotoxin:
- to test its effect on metabolism and hypoxia in human embryonic kidney (HEK293) cells[1]
- to test its cytotoxic effects in bovine mammary epithelial cells[2]
- as a standard for gamma radiation studies with food products and in cytotoxic studies using Hep G2 cells[3]
Biochem/physiol Actions
Ochratoxin A (OTA), a renal toxin, is produced majorly by Aspergillus and Penicillium fungal species.[1] It is immunotoxic, teratogenic[2] myelotoxic, and mutagenic.[3] It effectively interrupts the intestinal barrier functions.[2] OTA displays a long elimination half-life[3] and stimulates the major inflammatory cytokines release.[2]
Ochratoxin A is a mycotoxin found in food that is nephrotoxic and carcinogenic in the kidney and induces differentiation in cloned renal cell lines. Increases endoplasmic reticulum ATP-dependent Ca2+ pump activity.
Preparation Note
This product is also soluble in chloroform (9.80 - 10.20 mg/ml), methanol (10 mg/ml), ethanol (50 mM), and DMSO (100 mM).
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥97% (HPLC) | assay - | assay - |
| form powder | form powder | form - | form - |
| Quality Level 300 | Quality Level 100 | Quality Level 100 | Quality Level 300 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. -10 to -25°C |
| solubility ethanol: soluble | solubility DMSO: 50 mg/mL, nearly colorless | solubility methanol: soluble 5 mg/mL, clear, yellow(lit.) | solubility - |
| impurities Benzene, free | impurities - | impurities - | impurities - |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Carc. 2
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Which solvents can be used for an OTA standard solution? PBS, alcoholic solvents (methanol or ethanol)?
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