M2420

Monoclonal Anti-Monocyte Chemotactic Protein-1 antibody produced in mouse

clone 24822, purified immunoglobulin, lyophilized powder

• Synonym(s): Anti-CCL2, Anti-MCP-1
• UNSPSC Code: 51111800
• NACRES: NA.41
• MDL number: MFCD00282367
• Conjugate: unconjugated
• Clone: 24822, monoclonal
• Application: Neutral, WB
• Citations: 4

Properties

• biological source: mouse
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 24822, monoclonal
• form: lyophilized powder
• species reactivity: human
• technique(s): neutralization: suitable, western blot: suitable
• isotype: IgG1
• UniProt accession no.: P13500
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CCL2(6347)

Description

General description

Monocyte Chemotactic Protein-1 (MCP-1) is a chemotactic factor that belongs to CC chemokine family and can attract basophils and monocytes but not eosinophils or neutrophils. It is produced in keratinocytes, fibroblasts, hepatoma cells and Type II pneumocytes in response to IL-1. It has a crucial role in recruiting immune cells to the site of antigens as well as behaves as an inflammatory mediator which stimulates the directional migration of T cells and monocytes. Monoclonal anti-Monocyte Chemotactic Protein-1 antibody is suitable for neutralization, in which it will not neutralize the activity of recombinant human MIP-1α, recombinant mouse MIP-1α or recombinant human RANTES. Mouse anti-Monocyte Chemotactic Protein-1 antibody reacts specifically with human MCP-1/CCL2.

Immunogen

recombinant human MCP-1/CCL2 expressed in E. coli.

Application

Monoclonal anti-Monocyte Chemotactic Protein-1 antibody can be used in western blotting.

Biochem/physiol Actions

The antibody will neutralize the biological activity of recombinant human MCP-1.This antibody does not exhibit cross-reactivity with recombinant human RANTES, recombinant human MIP-1α, or recombinant mouse MIP-1α..

Physical form

Lyophilized from a 0.2 μm solution in phosphate buffered saline containing carbohydrates.

Preparation Note

Purified using protein A.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)