We have not done any such testing, but the following references may be helpful: https://jpet.aspetjournals.org/cgi/content/abstract/320/3/1013, https://molpharm.aspetjournals.org/cgi/reprint/66/1/187.
L9908
LY-294,002 hydrochloride
from microbial (Staphylococcus roseus), ≥98% (HPLC), solid, PI3K inhibitor
Synonym(s):
2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C19H17NO3 · HCl
CAS Number:
Molecular Weight:
343.80
UNSPSC Code:
12352207
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Pricing and availability is not currently available.
Product Name
LY-294,002 hydrochloride, solid, ≥98% (HPLC)
biological source
microbial (Staphylococcus roseus)
Quality Segment
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
DMSO: >5 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4
InChI
1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChI key
CZQHHVNHHHRRDU-UHFFFAOYSA-N
General description
LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.
Application
LY-294,002 hydrochloride has been used in the inhibition of:
- phosphoinositide 3-kinase (PI3K) in human lung cancer cell line
- autophagy in mesenchymal stem cells (MSCs).
- serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.
Biochem/physiol Actions
Specific cell permeable phosphatidylinositol 3-kinase inhibitor.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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This Item | |||
|---|---|---|---|
| form solid | form solid | form powder | form liquid |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO: >5 mg/mL, H2O: insoluble | solubility DMSO: 20 mg/mL, ethanol: soluble | solubility DMSO: 10 mg/mL, clear | solubility - |
| color white to off-white | color off-white | color orange-red | color - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| L9908-5MG | 04061833967072 |
| L9908-1MG | 04061833967065 |
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Can I use Product L9908, LY-294,002 hydrochloride, in conjugation with Wortmannin?
1 answer-
Helpful?
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What is the recommended concentration for using Product L9908, LY-294,002 hydrochloride?
1 answer-
One can use this product at 50 uM concentration.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the solution stability in DMSO for Product L9908, LY-294,002 hydrochloride?
1 answer-
After reconstitution in DMSO, aliquot and freeze the stock solution at -20 °C. DMSO stock solutions are stable for at least 1 month at -20 °C.
Helpful?
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